نام: رضا
نام خانوادگی: شیخ نژاد
محل تولد: زاهدان
تاریخ تولد: 27 دی 1330
دیپلم: دبیرستان تمدن زاهدان
لیسانس: دانشسرایعالی تهران
دکتری: بیوشیمی از دانشگاه ایالتی جورجیا-آمریکا
فوق دکتری: فیزیولوژی سلولی از دانشکده پزشکی دانشگاه ایالتی وین-دیترویت میشیگان
تخصص: بیولوژی مولکولی تحقیقات دارویی سرطان
سابقه کار: مرکز تحقیقات سرطان میشیگان
بازگشت به ایران:1387 شمسی
محل کار:شرکت تحقیقاتی مهندسی توفیق دارو-تهران
نوع تحقیق: ساخت داروهای ضد سرطان
مقالات: بیش از 30 مقاله و اختراع ثبت شدهی بین المللی
کتاب: 1. سرطان چیست؟
2. روانشناسی سرطان
ایمیل:
Sheikhnejad, Reza
Email:
Education:
University of Teacher Education Tehran/Iran B.S. 1974 Biology
Western Carolina University, NC/ USA M.S. 1981 Biology
University of Georgia, Athens, GA/USA Ph.D. 1985 Biochemistry
Awards, Fellowships, Grants:
NIH Postdoctoral Fellowship award 1986 Cell Physiology
American Cancer Society Institutional award 1994
Inventor of the year, second place/Life Science 1997
European Association for Cancer Research Member, 2011
Positions Held:
1985-1986 Postdoctoral Trainee, University of Georgia Department of Biochemistry, Athens, Georgia
1986-1988 Postdoctoral Fellow, Wayne State School of Medicine, Department
of Physiology, Detroit, Michigan.
1988-1994 Assistant Member, Karmanos Cancer Institute, Detroit, Michigan.
1994-1997 Research Associate, Wayne State School of Medicine, Department of Radiation Oncology, Detroit, Michigan
1997-2001 Scientific Director, Anti-Gene Therapeutics Inc. Ann Arbor, Michigan
2001-2003 Scientific Director, SenseGene Therapeutics Inc. Kalamazoo Michigan
2005-Present Consultant and shareholder, ProNAi Therapeutics, Inc
Kalamazoo, Michigan
2008-Present Program Director, Tofigh Daru (TODACO), Tehran/Iran
Patents &Publications:
• Sheikhnejad et al. “Methods and Compositions for Cancer Therapy” US/Patent No: 7,807,647 B2 Issued Oct. 5, 2010
• Sheikhnejad et al. “Methods and Compositions for The Inhibition of Gene Expression” US/patent NO.: 7,524,827B2 Apr. 28, Issued 2009
• Sheikhnejad et al. “Methods and Compositions for The Inhibition of Gene Expression” US/patent NO.: 7,498,315B2, Issued Mar.3, 2009
• Sheikhnejad et al. “Methods and Compositions for The Inhibition of Gene Expression” US/patent NO.: 2008/0152700 A1, Issued Jun. 26, 2008
• Sheikhnejad et al. “Methods and Compositions for Cancer Therapy” US/Patent No: 2007/0213285 A1, Issued Sep. 13, 2007
• Sheikhnejad G et al. “Methods and Compositions for The Inhibition of Gene Expression” L80003601CA/ CANADA Pending, 2007
• Sheikhnejad et al. “Methods and Compositions for The Inhibition of Gene Expression” US/patent NO.: 2006/0229267 A1, Issued Oct. 12, 2006
• Sheikhnejad et al. “Methods and Compositions for The Inhibition of Gene Expression” US/patent NO.: 2006/0198828 A1, Issued Sep. 7, 2006
• Sheikhnejad et al. “Methods and Compositions for The Inhibition of Gene Expression” US/patent NO.: 2006/0135455 A1, Issued Jun. 22, 2006
• Sheikhnejad et al. “Methods and Compositions for The Inhibition of Gene Expression” US/patent NO.: 2005/0287667 A1, Issued Dec. 29, 2005
• Christman, Judith K., Elkhorn, Sheikhnejad, Gholamreza “Substrate for den Nachweis von 5-C-DNS Methyltransferase von Säugetiere” Europäischen Patentschrift, EP 0756008 B1, DE 696 24 761 T2, Issued 11, 9, 2003
• Sufrin, Janice R., Christman, Judith K., Marasco, Canio Jr., Sheikhnejad, Gholamreza, “ Substrate for detection of mammalian 5-C-DNA Methyltransferase” European Patent No:, EP 0756 008 B1, Issued 13.11.2002
• Sheikhnejad, Gholamreza, “Compositions and Methods of Inhibiting Certain Genes” International Patent Publication Number: WO 99/24560, Published Date: 20 May 1999
• Sheikhnejad, Gholamreza, “Ras Antisense Inhibition” Patent Number: US 5874416, published: Feb. 23, 1999
• Sufrin, Janice R., Christman, Judith K., Marasco, Canio Jr., Sheikhnejad, Gholamreza, “ Substrate for detection of mammalian 5-C-DNA Methyltransferase” European Patent No:, EP 0756 008 A3, Issued 07.10.1998
• Sufrin, Janice R., Christman, Judith K., Marasco, Canio Jr., Sheikhnejad, Gholamreza, “ Substrate for detection of mammalian 5-C-DNA Methyltransferase” European Patent No:, EP 0756 008 A2, Issued 29.01.1997
• Sufrin, Janice R., Christman, Judith K., Marasco, Canio Jr., Sheikhnejad, Gholamreza, “ Substrate for detection of mammalian 5-C-DNA Methyltransferase” US Patent No:, 5,652,105, Issued Jul. 29, 1997
• Marquez VE, Goddard A, Alvarez E, Ford H. Jr., Christman JK, Sheikhnejad G, Brank A, Marasco CJ, Sufrin JR, O’Gara M, Cheng X. “Oligonucleotides containing 5,6-dihydro-5-azacytosine at CpG sites can produce potent inhibition of DNA cytosine-C5-methyltransferase without covalently binding to the enzyme” Antisense & Nucleic Acid Drug Development, 9(4):415-421, (1999)
• Sheikhnejad G, Brank A, Christman JK, Goddard A, Alvarez E, Ford H. Jr Marquez VE, Marasco CJ, Sufrin JR, O’Gara M, Cheng X. Mechanism of Inhibition of (cytosine-C5)-Methyltransferase by Oligonucleotides containing 5,6-dihydro-5-azacytosine. J Mol Biol; 285 (5): 2021-34, (1999)
• Christman JK, Sheikhnejad G, Marasco CJ, Sufrin JR, 5-methyl-2-deoxycytidine in single stranded DNA can act in cis to signal de novo DNA methylation. Proc Natl Acad Sci (PNAS),; 92: 7347-7351, (1995)
• Christman JK, Sheikhnejad G, Dizik M, Abileah S, Wainfan E. Methyl-Deficiency, DNA methylation and cancer studies on the reversibility of the effects of a Lipotrope Deficient Diet. J. Nutr. Biochem.; 4: 672-680, (1993)
• Christman JK, Chen L, Sheikhnejad G, Dizik M, Abileah S, Wainfan E. Reversibility of Changes in Nucleic Acid Methylation and Gene Expression induced by Severe Dietary Methyl Deficiency. Carcinogenesis; 14: 551-557, (1993)
• Christman JK, Chen L, Sheikhnejad G, Dizik M, Wainfan E. A possible link between dietary methyl deficiency and hepatocarcinogenesis. In: The Role of Nutrients in Cancer treatment, Report of the 9th Ross Conference on Medical Research; 60-65, (1991)
• Wainfan E, Dizik M, Sheikhnejad G, and Christman JK. Rapid and Reversible Changes in DNA Methylation and Gene Expression in Liver of Rats Fed Cancer Promoting Methyl-Deficient Diets. The 6th Sardinian International Meeting in Chemical Carcinogenesis; (1991)
• Christman JK, Sheikhnejad G, Dizik M, Abileah S, Wainfan E. Increased rat Liver DNA and tRNA Methyltransferase Activities in Response to Feeding of Methyl-Deficient Diets. Proceedings of American Association for Cancer Research; 32: 143, (1990)
• Dizik M, Sheikhnejad G, and Christman JK. Early Changes in Nucleic Acid Methylation and Gene Expression in Livers of Rats Fed Cancer Promoting Methyl-Deficient Diets. FASEB; 4510 , (1990)
• Dizik M, Wainfan E, Sheikhnejad G, and Christman JK. Rapid and Reversible Changes in DNA Methylation and Gene Expression in Liver of Rats Fed Cancer Promoting Methyl-Deficient Diets. Proceedings of American Association for Cancer Research; 32: 141, (1990)
• Sheikhnejad G. Polasek, D.M. and Yingst, D.R. Purification of an Inhibitor of Ca-ATPase from Human Red Blood Cells. J. General Physiology, Boston, MA; (1988)
• Srivastava PN, Sheikhnejad G, Hosken FR, Malter H and Brackett M. Inhibition of Fertilization of Rabbit Ova in vitro by a Polyclonal Antibody to the Inner-Acrosomal Membrane of Rabbit Sperm. J. Exp. Zoology; 238: 99-102, (1986)
• Sheikhnejad G and Srivastava PN. Localization of Antigens on the Inner-Acrosomal Membrane of Rabbit Spermatozoa by Immuno-Fluorescense labeling. Gamete Research; 13: 317-325, (1986)
• Sheikhnejad G and Srivastava PN. Isolation and Properties of a Phosphatidylcholine Specific Phospholipase C from Bull Seminal Plasma.
JBC; 261: 7544-7549, (1986)
• Sheikhnejad G. and Srivastava, P.N. The Purification of Phospholipase C and its Role in Sperm Acrosomal Reaction; 13th International Congress of Biochemistry in Amsterdam, Holland; (1985)
• Rahi H, Sheikhnejad G and Srivastava PN. Isolation of the Inner-Acrosomal Membrane Complex from Rabbit Spermatozoa. Gamete Res.; 7: 215-226, (1983)
Reza Sheikhnejad, ProNAi Therapeutics ProNAi raising vc for phase two